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Stimulation of IR upregulates both mitogen-activated protein (MAP)/extracellular signal-regulated kinase and phosphoinositide 3-kinases/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathways and subsequently leading to inhibiting of apoptosis and promoting cell migration and proliferation [33]

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Both the normoxic and hypoxic conditions exhibited comparable levels of positive markers (CD29 and CD73) and negative markers (CD34 and CD45) (Figure 4a)

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