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Many initial denials get overturned with proper documentation of obesity-related comorbidities, previous weight loss attempts, medical necessity

Novo Nordisk tried to acquire the company, but it ultimately lost out to Pfizer, which completed the acquisition that could ultimately be worth more than $10 billion.

Heart rate increases were dose-dependent and followed a consistent pattern across all treatment groups

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In the future, a multidimensional line of evidence is needed to clarify the source of GLP-1RA effects in IBD, including in vitro experiments to confirm direct actions, animal models designed to exclude metabolic interference, and clinical data adjusted for metabolic confounders

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