Merritt K, Egerton A, Kempton MJ, Taylor MJ, McGuire PK
doi: 10.1007/s00125-017-4315-2 135 HeiseTMariADeVriesJHUrvaSLiJPrattEJet al
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In this review we will focus on (a) GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis (ischemic heart disease and stroke), (b) importance of oxidative stress and antioxidants in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19 disease, (c) significance of GSH to counteract persistent damaging inflammation, inflammaging and early (premature) inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and (d) new therapies that include antioxidant defenses restoration
The research showed that GLP-1 receptor activation reduces Cyp2e1 expression by approximately 40-60% in animal models
