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In addition, an improvement in the levels of inflammatory biomarkers was demonstrated

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Zhao H, Osborne OJ, Lin S, Ji Z, Damoiseux R, Wang Y, Nel AE, Lin S., "Lanthanide Hydroxide Nanoparticles Induce Angiogenesis via ROS-Sensitive Signaling", Small 12 (32): 4404-4411 (2016)

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Strategies have been used to counteract this by incorporating synergists that inhibit cytochrome P450 such as Piperonyl-butoxide (PBO) into existing interventions (Protopopoff et al