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This is a reversible condition characterized by diffuse deposition of brown-black lipofuscin pigment in macrophages of the mucosal lamina propria and widely thought to be linked with chronic anthraquinone laxative use [20]

Overweight or obese individuals might metabolize the drug differently than those with a normal weight, potentially leading to a higher incidence of stomach cramps

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In addition, FSP1 and GCH1, two other markers of ferroptosis [19, 20], are also transcriptionally upregulated during acute disease, possibly counteracting the loss of GPX4 (Fig