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Your dose does not need to increase

Manganese: Is a cofactor for the protein that forms superoxide dismutase (SOD), an enzyme that is crucial for the antioxidation of cells May support the suppression of mast cell activation May rebalance gut dysbiosis The amount of manganese in Calm is small enough to ensure sustainable use, but potent enough to provide effective daily care

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To make them work, they come with significant restrictions: you must take them on a completely empty stomach with a tiny sip of water, and wait a strict 30 minutes before consuming anything else