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Curry, S., Mandelkow, H., Brick, P

Incorporation of Ga(III) in place of iron disrupts the iron-dependent redox process as Ga(III) cannot be reduced to Ga(II) under physiological conditions, and thus cannot be liberated from porphyrins by haem oxygenase (Choi et al., 2019)

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Gastrointestinal adverse events were the most commonly reported and were more frequent during dose escalation

Industry experts note that targeted combinations of research-selected strains working through complementary mechanisms may offer theoretical advantages over single-strain approaches or generic multi-strain probiotics without metabolic focus