Excessive generation of ROS within ovarian, adipose, and hepatic tissues overpowers antioxidant defenses, leading to oxidative damage of lipids, proteins, and mitochondrial DNA ( Androgen excess exacerbates redox disequilibrium by promoting NADPH oxidase activity and mitochondrial ROS production, while simultaneously impairing follicular maturation and oocyte quality ( Figure 1 represents the involvement of redox imbalance and endocrine dysregulation in the ovary, leading to hyperandrogenism or PCOS
Precautions and side effects Watch out for possible side effects such as skin reactions and severe abdominal pain
A total of 970 potential target genes were obtained from those databases
1997 [Google Scholar] 24.Olson KR, Straub KD
Both compounds exhibited a remarkable growth-inhibitory activity towards leukemic and melanoma cells (Gunnarsdottir and Elfarra, 2004)
[149] George Whipple, George Minot and William Murphy were awarded the Nobel Prize in 1934 for their work on the vitamin