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At this concentration, the maximum comfortable dose per vial is approximately 1.25 mg weekly, since higher doses would require nearly the full vial each week

Comment: A commenter stated their opinion that CMS' estimate of the costs associated with implementing the Information Transfer PRO-PM are too low and does not believe the utility of the measure is outweighed by the burden

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For example: Selank, with a molecular weight of 751 daltons (Da), achieves an impressive 92.8% bioavailability through intranasal administration and detectable blood levels appear within 30 seconds