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doi: 10.1093/neuonc/noz028

Rectal suppositories bypass the gastrointestinal tract, which can be advantageous in situations where the oral route is compromised or when a rapid onset of action is desired

Custom Titration: The dose is gradually increased by your provider to maximize results while minimizing side effects

If methylfolate causes side effects (restlessness, irritability, feeling wired): reduce dose, try niacin (50100 mg) every 30 minutes until side effects cease, switch to folinic acid, or switch methylcobalamin to hydroxocobalamin. You do not need genetic testing

For more detailed guidance on injection site selection and rotation, see our guide on where to inject retatrutide

Unlike drinking water or swallowing supplements, this method bypasses your digestive system entirely