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In support to the significant potential of mitomiRs in AD, miR-181a is recently reported to affect mitochondrial glucose metabolism and increase mitochondrial dysfunction, while clinically it is upregulated in MCI patients' plasma and has been reported as a promising early diagnostic marker to predict progression to AD (Ansari et al., 2019)

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Retatrutide remains investigational, and the Phase 3 TRIUMPH program is the key regulatory pathway to watch