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While supplemental folic acid has the greatest homocysteine-lowering effect of the B-vitamins, co-supplementation of folic acid plus vitamin B 12 can lower homocysteine levels even further

However, elderly patients are more likely to have reduced renal function and hepatic reserve, increasing their susceptibility to adverse effects with prolonged or high-dose use

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Med 12 , 541548 (2006)

Several researchers have come to the same conclusion when trying to explain this fact [15]

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