Statements Author contributions AC and GLG contributed to conception of the review
Several Phase 2 trials are currently testing semaglutide for alcohol use disorder, including studies registered as NCT05895643 and NCT05520775
The trade-off is that prepaid bundles can feel restrictive, provider access is limited, and branded medications remain costly
For instance, branded medications may have storage instructions that differ from compounded versions
The most active hybrids were selected and native side chains were introduced in the oligourea triads in new rounds of synthesis with focus on recovering the most important side chain interactions: D9, Y13, E15, F22 and I23
In a separate study , published in JAMA in August 2025, the same researchers found that, across ages, GLP-1s were associated with lower risk of some obesity-related cancers, such as endometrial, ovarian, and meningioma cancers, but with an increased risk of kidney cancer, and nonsignificant changes for several other cancers
