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Full-length CK-18 is released during necrosis (uncontrolled cell death), while a caspase-cleaved fragment (ccK18) is released during apoptosis (programmed cell death) so measuring both can reveal the type of cell death occurring, information with real prognostic value

Similarly, Doncheva et al

It may interact directly with HGF and induce a subtle structural change, creating an enhanced Super HGF form that binds c-met more strongly and resists nitration. To test whether this effect holds up in living tissue, the researchers used a mouse model of muscle atrophy caused by tail suspension

Stem Cells 35 (12), 23232330