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The diarrhea and dehydration caused by the drug can lead to increased blood viscosity, increasing the risk for the formation of blood clots

Replacing the pyrazole methyl with chlorine and the p-chlorophenyl with a trifluoromethyl-BCP enhances metabolic stability, cellular penetration and safety while improving target engagement

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However, these versions of oral tirzepatide have not been approved by the FDA, and there is insufficient clinical data to demonstrate that oral tirzepatide works as effectively as the injectable formulation