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Across six randomized, double-blind, placebo-controlled trials, AOD-9604 showed no effect on serum IGF-1, no impairment of glucose tolerance, and no insulin resistance all common problems with full GH therapy (Stier et al., 2013)

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The actin-binding region itself has been linked to vascular activity: a 2003 study in the FASEB Journal reported that the site promoting actin interaction is also associated with angiogenic activity in experimental models

Cyanocobalamin, by contrast, requires enzymatic conversion in the liver and tissues to become active