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Effects on Glycemic Control : DPP-4 inhibitors prevent the inactivation of incretin hormones (glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP))

While several studies demonstrated non-significant or borderline effects for myocardial infarction, stroke or cardiovascular death, pooling the data revealed significant reductions in MACE and all-cause mortality