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Although the liver is also the principal source of circulating IGFBP-3 and ALS, other tissues have been proposed to produce these factors[48, 49]

Chemically, the fatty acid derivatization of target molecules can be accomplished through several methods, including the direct coupling of fatty acids to the peptide backbone or via a linker and/or spacer

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Iodothyronine deiodinases (thyroid hormone deiodinases) The thyroid gland releases very small amounts of biologically active thyroid hormone (triiodothyronine or T 3 ) and larger amounts of an inactive form of thyroid hormone (T 3 precursor: thyroxine or T 4 ) into the circulation

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