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GCL is considered the speed limiting enzyme of synthesis since overexpression of GS does not increase GSH levels while overexpression of GCL increases the synthesis of GSH (61) (Figure 3)
Some clinical reports describe improvements in hair density and follicle health in patients using GHK-Cu-containing topical formulations or injectable protocols, though more controlled human trials are needed in this area
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Formation of gamma-glutamycyst(e)ine in vivo is catalyzed by gamma-glutamyl transpeptidase
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Most (8085%) of the cellular GSH are in the cytosol, 1015% is in the mitochondria and a small percentage is in the endoplasmic reticulum (Figure 2) (3, 2428)
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