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Thus, we further adjusted for DPN in model 2

95% CI: 3.51-6.21, P=0.0011) ( Mendelian randomization (MR) facilitates the study of the causal relationships between exposure factors and outcomes ( 2 Materials and methods 2.1 Study design Figure 1 showed three key assumptions of this MR study: SNPs are strongly associated with appendectomy or appendicitis

Transgenic techniques are routinely used to introduce human disease genes or other genes of interest into strains of laboratory animals in order to study the function or pathology involved with a particular gene

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In addition, virtual drug screening offers a promising approach to discover candidate compounds or small molecules capable of selectively enhancing the interaction between NEDD4 and YAP1 [66]