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While mPFC Glu levels remained unaffected, the GABA signal was significantly reduced in THC exposed animals, suggesting lower inhibitory drive in the mPFC network and a strong increase of EPSC frequency consistent with previous findings [4, 5]

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TTC5 has previously been shown to downregulate ATP synthase activity, which sensitizes cells to mitochondrial-dependent apoptosis via enhanced p53 activity (72)