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Ni et al., 2021
Mounjaro (tirzepatide injection) is approved for diabetes and weight control in adults with obesity (BMI 30+) or overweight (BMI 27+) with related health problems like high BP, cholesterol, diabetes, sleep apnoea, or heart disease 17
More serious but rare adverse effects include: Pancreatitis : Seek immediate medical attention if you experience severe, persistent abdominal pain radiating to the back, particularly if accompanied by vomiting Diabetic retinopathy complications : The SmPC notes that rapid improvement in glucose control has been associated with temporary worsening of diabetic retinopathy, particularly in patients with pre-existing retinopathy and those on insulin [1] [18] Acute kidney injury : Particularly in the context of severe dehydration from gastrointestinal side effects Gallbladder disease : Rapid weight loss may increase the risk of gallstones Thyroid considerations : Semaglutide has been associated with thyroid C-cell tumours in rodent studies, though the relevance to humans remains uncertain
As CKD progresses, the TMAO levels in patients gradually increase
In C2C12 myotubes, follistatin-344 at 100500 nM produces: pSMAD2 6878%, Atrogin-1 mRNA 4452%, MuRF1 mRNA 3846%, myotube diameter +2228% at 96h
