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370 Two clinical trials suggested that lower-dose methazolamide (100200 mg daily) had similar prophylactic efficacy comparable to higher dose of acetazolamide (500 mg daily)

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Accordingly, approved indications expanded in early 2024 to include not only reduction of hyperglycemia, but also weight management in non-diabetic patients, and even cardiovascular risk reduction in patients with elevated weight and comorbid cardiovascular disease