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Since peripheral 5-HT cannot cross the BBB, central serotonin is synthesized from Trp, which is transported through the BBB from blood circulation (170)

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These long-range interactions are present in the Reed-Nijhout (and reduced) models (see also Nijhout et al., Other aspects of the model that are worth exploring further are the effects of compartmentalization on vitamin B 12 HcyGSH metabolism, in particular, the export of Hcy directly into the blood