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Barrette et al

According to ClinicalTrials.gov, several bimolecular combinations alongside the dual GLP-1/GIP agonist tirzepatide are currently under investigation in phase 2 trials including eloralintide (NCT06603571), an amylin receptor agonist

This sustained sensitivity may explain why some individuals report consistent benefits from low doses maintained over many months

The success of GLP-1R agonists is usually hindered by their adverse gastrointestinal effects, leading to reduced compliance

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Tang et al., 2012