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In conclusion, the paper provides evidence that the reduction of GLP-1+ cells is a general feature of ileal and colonic inflammation in mice and humans and is likely due to altered epithelial differentiation driven by changes in cellular metabolism, particularly mitochondrial dysfunction.

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Function of PI3K in thymocyte development, T cell activation, and neutrophil migration

Awany, D

The mice were maintained under conventional conditions or specific-pathogen-free conditions and fed AIN93G, 0.00038% LBI/AIN93G, or 0.00112% LBI/AIN93G from 4 to 6 weeks old