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Psychiatry Neurosurg

Generally I refer to both of these drugs as incretin medicines because they work to enhance natural gut hormones called incretins (GLP-1 and GIP)

Animal studies show that DPP-4 inhibition does not improve glucose homeostasis in mice with genetic deletion of GLP-1 and GIP receptors, highlighting the critical role of GLP-1 in the mechanism of action of DPP-4 inhibitors (46)

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Ding, D-C., Huang, Y-C., Liu, J-Y

BOSTON and SHANGHAI, June 18, 2025 (GLOBE NEWSWIRE) -- Eccogene, a clinical-stage biopharmaceutical company developing next-generation oral small molecule therapeutics for chronic cardiometabolic and inflammatory conditions, today announced that the first patient has been dosed in a Phase 1b clinical trial of AZD5004/ECC5004 in China