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doi: 10.3390/molecules27248855 29 KimR-OJoM-ASongJKimI-CYoonSKimW-K

Unlike most mammals, humans cannot synthesize vitamin C internally due to a mutation in a key enzyme that occurred millions of years ago, meaning we depend entirely on food and supplementation to maintain adequate levels (10)

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While plasma membrane localization is ideal for eNOS activation, this also exposes eNOS to external factors like ox-LDL and high-density lipoprotein (HDL)

A subsequent study by Mihail Ionescu and colleagues demonstrated that even during prolonged stimulation, the pulsatile nature of GH secretion remained preserved

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