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Incretins are largely degraded by DPP-4 in vivo, which can be hindered by substitution of first three residues or increasing steric hindrance

doi: 10.1007/s00280-005-1014-3 18 KittichaiV.NguitragoolW.GaelleH.MbendaN.CuiL

7: e2427258) GLP-1 GLP-1 GLP-1 2( GLP-1 GLP-1 GLP-1 BMI35 kg/m 2 GLP-1 202312 2025 3

Although the majority of first-time prescriptions occurred in the 45-64 age group, a higher proportion of patients with off-label prescriptions were female (off-label: 69%, on-label: 61%) and between 18-25 (off-label: 30%, on-label: 22%)

It also identified dosing errors as a specific concern, including patients measuring and self-administering incorrect doses and clinicians miscalculating doses, and reports that may relate to prescribing beyond approved labeling more product per dose, more frequent dosing, or faster escalation