Hypothalamic regulation of the pituitary hormones
If acne is severe, persistent despite treatment, causing scarring, or significantly affecting your quality of life, request referral to a dermatologist
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This may include people with active cancer concerns, immune disorders, uncontrolled chronic illness, pregnancy or plans for pregnancy, complex medication regimens, bleeding disorders, severe allergies, kidney or liver concerns, unexplained symptoms, or a history of poor reactions to injectable products
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According to NICE guideline NG198 on acne management, first-line options include fixed-combination topical treatments such as adapalene with benzoyl peroxide or benzoyl peroxide with clindamycin
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