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Mechanistically, TNF- induces SLC7A11 and the glutamate-cysteine ligase modifier subunit by activating nuclear factor-B (NF-B), which upregulates the regulatory subunit of glutamate-cysteine ligase catalytic (GCLC) and glutamate-cysteine ligase catalytic, ultimately enhancing cellular GSH biosynthesis and protecting against lipid peroxidation-induced stress, thereby increasing ferroptosis resistance (89)

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Animal models , where researchers monitored growth hormone release and related hormonal changes

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But they come with downsides: high costs, insurance hoops, injections, and potential side effects