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Follow the updated guidance for pausing medication
Clinical context: The SURMOUNT-1 trial showed tirzepatide produced an average 22.5% body weight loss over 72 weeks
Originally developed for the management of type 2 diabetes, semaglutide has also shown promise in the field of weight management
These are analogs of GLP-1 with longer half-lives and sustained action, effectively enhancing insulin secretion and inhibiting glucagon release
The frequency question becomes "zero doses" once pregnancy is planned or confirmed
After pre-conditioning in the presence or absence of 50 nM Exendin-4 for additional 18 hours, culture medium was changed to serum-free DMEM containing 1 mM sodium pyruvate, without glucose and sodium bicarbonate
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