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[1] [3] Given that obesity is itself a major cardiovascular risk factor, significant weight loss is generally associated with improvements in blood pressure, lipid profiles, and markers of systemic inflammation, all of which may benefit heart health

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Whether this mechanism translates into greater weight loss than dual-agonist therapies remains a hypothesis no head-to-head clinical trials have yet been conducted

None of the participants discontinued treatment due to gastrointestinal events or other reasons