For APOE4 carriers specificallywho show accelerated mitochondrial dysfunctionthis pathway represents a mechanistically rational intervention target
doi: 10.1097/ICO.0b013e31812f6d14
Notably, a similar phenomenon was observed in neurons from patients with MS, characterized by upregulated STING expression and markedly reduced STIM1 expression, suggesting that STIM1-STING-GPX4 axis-mediated ferroptosis is closely associated with neuronal injury in human MS pathology (Woo et al., 2024)
Integrating predicted transcriptome from multiple tissues improves association detection
Vitamin D is predominantly circulated as 25-hydroxyvitamin D (25(OH)D) and thus converted by 1-hydroxylase into its active form, 1,25-dihydroxyvitamin D [1,25(OH)2D]
Surgery becomes necessary when conservative treatments fail or neurological deficits worsen