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For many people it has a strong biological and genetic basis, rooted in ancestors who survived famine by being extraordinarily good at storing calories

Semaglutide, among other antidiabetic drugs, has shown an association with cancer as it alters the rates of tumorigenesis and proliferation

Genetically predicted glucose-dependent insulinotropic polypeptide (GIP) levels and cardiovascular disease risk are driven by distinct causal variants in the GIPR region

The key is not to overeat

Lifestyle Counseling: Nutrition: Recommends a moderate-calorie, balanced diet focusing on whole grains, lean protein, and vegetables

If gastrointestinal symptoms are problematic, adjusting the timing may be considered, with reassessment after several weeks