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Croatian researchers first isolated and characterized this peptide in 1993 from a larger protein found naturally in human gastric juice

How it works The best-documented mechanism runs through VEGFR2, a receptor that triggers new blood vessel formation, paired with the Akt-eNOS pathway, which generates nitric oxide to support vascular repair and restore blood flow to damaged tissue (Rodgers et al., 2025)

1 3 This matters because a healing tendon attached to a muscle with poor neural activation wont function properly, no matter how good the collagen looks

bioRxiv , 060012

Best used as a long-term maintenance solution after an initial course of IV therapy

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