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In September 2025, Eli Lilly canceled one of its two Phase 2 bimagrumab trials, though the company cited strategic business reasons rather than safety signals, and a second trial in non-diabetic obesity patients continued

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Together, these mechanisms contribute to a healthier metabolic profile, alleviating the burden of insulin resistance and reducing ectopic fat accumulation

When considering the science behind GLP-1s, this outcome aligns with expectations

That glucagon receptor component is the critical differentiator