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Several mid-stage trials will read out in 2025 to provide important proof points for novel MoAs and their potential for differentiation, e.g., Lillys bimagrumab (activin/myostatin type II receptor inhibitor) in combination with semaglutide, aiming to deliver weight loss while preserving muscle mass (phase 2b)
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Research applications include neuropeptide pharmacology, peptide-signaling pathway investigation, receptor-ligand interaction studies, signal transduction research, structure-function analysis, and mechanistic evaluation of peptide-mediated regulatory networks
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