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Knock out of the enzyme protein-tyrosine phosphatase 1B (PTP-1B) that is , responsible for inhibiting leptin and insulin signaling in the hypothalamus and other brain areas resulted in animals gaining less weight when fed a high-calorie diet than did normal controls (23.)

10.1002/med.21257 [DOI] [PMC free article] [PubMed] [Google Scholar] Njlsson R., and Norgren S

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ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study