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GL: Funding acquisition, Project administration, Writing original draft, Supervision, Writing review & editing, Conceptualization

Summary: Retatrutide can cause gastrointestinal symptoms including heartburn-type discomfort, most likely due to its GLP-1 receptor activity slowing gastric emptying and increasing intra-gastric pressure

Retatrutide is currently being investigated in clinical trials and has not yet been approved

In the COR clinical trial program, patients taking Contrave alongside diet and exercise modifications lost an average of approximately 56% of their body weight over 56 weeks, compared with placebo

Symptoms (muscle cramps, arrhythmias, fatigue) and dietary history often provide better clues than blood tests