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In PD, the positive Phase 2 Exenatide PD2 trial was followed by a negative Phase 3 Exenatide PD3 trial, whereas the LIXIPARK trial showed modest motor benefits

10.1093/humrep/dew329 Hum Reprod

Effects of oral liposomal glutathione in altering immune responses against Mycobacterium tuberculosis and the Mycobacterium bovis BCG strain in individuals with type 2 diabetes

This matters for dosing decisions

Dose escalation: 7mg once daily for 4 weeks, then 14mg once daily

These delivery constraints likely contribute to the heterogeneous efficacy signals reported with empiric biologics and underscore the need for protocols that explicitly address localization, sequencing, and persistence of therapy