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Unlike prior reports of fasting beyond 21 days in non-obese individuals [11, 12], this case demonstrates substantial weight loss (125 pounds) accompanied by improvements in depression, anemia, hypoxia/hypercapnia, functional status, and left ventricular (LV) mass

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Science Advances , 7 (2)

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Our results showed that the contribution of the TSS pathway on de novo cysteine synthesis and GSH generation is only detectable under cystine-restricted conditions, and such function is dimmed when cystine is supplemented at supraphysiological concentrations