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For example, homocysteine (Hcy), an amino acid involved in DNA methylation, facilitates GPX4 methylation that leads to upregulation of oxidative stress and ferroptosis in nucleus pulposus (Zhang et al., 2020c)

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According to NICE guidance (NG28), treatment intensification should be considered when HbA1c rises to 58 mmol/mol (7.5%) or higher on dual therapy

62 with modifications 63

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