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Date : DMF Number : 35467 Submission : 2021-08-20 Status : Inactive Type : IV Product Web Link USDMF GDUFA DMF Review : N/A Rev

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It is especially this kind of adipose tissue that is believed to drive a large part of the pathological effects of excess body weight ( The reductions in ROS and systemic inflammation, in combination with improvements in the other cardiometabolic parameters, are also thought to mediate the substantiated but so far formally unconfirmed kidney-protective effects of GLP-1 RAs, which may also directly or indirectly carry a HF-related benefit, considering that CKD is a prominent risk factor for HF (von Scholten et al., 2022)