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Activation of the NLRP3 inflammasome leads to the cleavage of procaspase-1 into its active form, which in turn processes proinflammatory cytokines such as IL-1 and IL-18 and drives pyroptotic cell death via Gasdermin D activation

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He charters a single-engine plane that brings him to Seattle in 40 minutes

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Studies show that ROS play an important role in the pathogenesis of kidney damage caused by contrast agents and that it might be possible to reduce this damage by antioxidants such as MESNA [22]

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