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Schedule: Once-daily subcutaneous injections in 4-week cycles (commonly 4 weeks on, 4 weeks off), repeated as needed

Excess cobalamin in the blood showed barely detectable binding to TC II (Andrs et al., 2013)

CONCLUSION: These studies in anesthetized rabbits demonstrate that the moderate pressor effect of hydroxocobalamin is not related to the formation of cyanocobalamin but is very likely related to the scavenging of nitric oxide by hydroxocobalamin

The pancreatic secretion of intrinsic factor is reduced or absent, secondary dysbiosis of the intestine is common, and the mucosa may be compromised by the presence of excessive bacterial numbers and toxic metabolites

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