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Studies indicated that microbial dysbiosis in IgAN disrupts intestinal barrier integrity and metabolic balance, leading to the proliferation of pathogenic bacteria and a reduction in beneficial metabolism, thereby upsetting systemic immune homeostasis [142, 143]

For example, the glutathione conjugate of hexachlorobutadiene is processed in the kidneys into reactive intermediates, leading to nephrotoxicity

B12 is used to initially treat B12 deficiency and anaemia

This article explains how each agent works, what the current evidence shows, the safety considerations patients should understand, and how to access emerging obesity treatments safely through regulated NHS and clinical trial pathways

No validated human dose, half-life or safety programme was identified