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[PubMed: 34081385] 94

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Given the anti-viral role of M1-M, HBV infection should theoretically only be productive if the activation of pro-inflammatory response by the resident Kupffer cells, as well as circulating monocytes (that could be recruited to the site of infection) can be avoided

For context, tirzepatide's SURMOUNT-1 Phase 3 trial showed mean weight reductions of 20.9% at the highest dose (15 mg) over 72 weeks