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COP1 Y491 and H578 form hydrogen bonds with c-Jun Q230 and M235 respectively

In addition to immune cells, the HRH2 gene is expressed in gastric parietal cells where the receptor plays a critical role in the regulation of gastric acid production in response to histamine

While causality remains debated, GLP-1 receptor agonists associate with increased pancreatitis risk in some populations

[PubMed: 17465615] 155

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Neuronal effects of GLP-1MK-801 To understand the biological underpinnings of the metabolic benefits of GLP-1MK-801, we performed RNA sequencing (RNA-seq) and MS-based proteomics analyses on hypothalami from DIO mice treated with vehicle, GLP-1, MK-801 or the GLP-1MK-801 conjugate for 5 days (Fig