10.1007/s11419-021-00597-4 43 RahnemaC
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Ubiquinone is more common and has been more comprehensively studied for more potential benefits in humans.33 Meanwhile, ubiquinol has demonstrated potentially superior bioavailability, though we don't yet have compelling data showing its more effective at specific tasks other than increasing serum CoQ10.34 More research is certainly needed, and CoQ10 research continues unceasingly
Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity
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This phenomenon, sometimes called tolerance or dose creep, is reported anecdotally with tirzepatide, though the clinical trial data does not show significant tolerance development at fixed doses over 72 weeks
